Fucosidase (Thermophilic, His tag)

Fucosidase (Thermophilic, His tag) 為一嗜熱性岩藻糖苷酶,可在廣泛的溫度範圍內(37至97°C)展現不同的活性。此產品最佳活性溫度為 70°C 或更高。在70°C時,它優先切割 Fucα1,2 鍵結,其次是 Fucα1,3、Fucα1,4 和 Fucα1,6 鍵結。在37°C時,該酶功能則主要是切斷 α1,2 鍵結的岩藻糖。Fucosidase 透過調節醣基組成,參與許多生理機制,包含發炎、細胞訊息傳遞與腫瘤成長。

Package: 200 U

SKU: AP9015 Category: Tags: ,
  • Official Name: Thermophilic Fucosidase
  • Specificity: Thermophilic Fucosidase is active at a wide range of temperatures (37 to 97°C), with an optimum of 70°C or higher. At 37°C, it primarily releases α1,2-linked fucose. At 70°C, it preferentially cleaves Fucα1,2 > Fucα1,3 ≈ Fucα1,4 ≈ Fucα1,6 linkages. No detectable activities of proteases or other glycosidases are observed.
  • Content: Purified lyophilized powder
  • Tag: 8x His tag at N-term, which can be removed by digestion with FasTEV
  • Reconstitution: Dissolve the lyophilized product in 100 μL of molecular grade water to make a 2,000 units/mL solution in the Buffer.
  • Buffer: 50 mM Tris, 100 mM NaCl, pH 7.5
  • Storage: -20 °C as powder. Once reconstituted, 4 °C for five days  or -20 °C for up to six months. Avoid freeze-thaw cycles.
  • Unit Definition: One unit is defined as the amount of Thermophilic Fucosidase required to catalyze the release of 1 nmole p-nitrophenol (pNP) from p-nitrophenyl-α-L-fucopyranoside (pNP-Fuc) per min at 37°C in 100 μL 1X Reaction Buffer 4 (50 mM Tris, 100 mM NaCl, pH 7.5).

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